microcrystalline cellulose msds fmc

II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Product Name Cellulose microcrystalline. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. Alginate drug delivery harnesses the unique properties of seaweed for premier performance in multiple pharmaceutical and nutraceutical applications; they impart viscosity in solutions and even form a three-dimensional gel in the presence of calcium ions. JRS Pharma: PROSOLV SMCC 90 LM: Microcrystalline Cellulose, Colloidal Silicon . No. More than 65 years later, Avicel continues to command global acceptance, with no signs of its popularity waning. FMC, JRS and Mingtai were estimated to hold for . Heavy metals, % NMT 0.001 Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. \C[i+rY2$V,,WT#_)3K?=/fW%[,lE"V?C PipEAz_xO;`cZsC0qcx;@tp]c*T7ge @Mty?]@SNmpf/]q#I,G1I?SR.@z*Xb KjR hb{T$CQrr Yx%O@~57eL5S\r-|EZ)Y.C]KuIlW]@12KY,S]C"e%b*|YX122igjl; @! ,}b;XQ})+l{~d_=sUtl V"CbKas+;fc>]bt#F,Md]]!5xae ;}rr^NI]rUc^,5Lc(fyyp*a=~U}WveuTLYX/ _V{#* g(*Rrm0gyv9i@0UT:A+{eW/y BS3_!Qv rt^BN! 1.3. MATERIAL SAFETY DATA SHEET Lattice NT Microcrystalline Cellulose MSDS Ref. Microcrystalline cellulose is an exceptional material and one of the most widely used excipients in the pharmaceutical field. {ddn(Y?I#K-}t|l #:FHF'D)/)"{k\pM @LRvdSbi#$yg+\0-U VE-2CZ*K&V.MiLeu86)23NI+6tkLSfmWuR.T\>;8]$ipHJ_)*P.FHyD R^PQ4EC l 4h+:6:]=3?B}Y#eAs(l)V6IOG,OM4'R3#^Op?gYZ; m#6@6O$ ;Ro|U$NSs*\neT &CcB7ysrg7;6Eax $R9+q,)}YK-0/SI0K}d WQC}>e|Gs_Q'+mB| X{URv/Z'` 4w'8sC~ cON&pIk:F/Q&u~.S{"% pg:lfx -. 1.5% w/w), especially designed for formulating active pharmaceutical ingredients (APIs) with a high sensitivity for moisture. Looking for FMC'searnings news? If breathing is difficult or if . The product would later go on to be commercialized under the brand name Avicel by FMC Corporation. Created Date: 2/10/2020 8:51:41 PM . Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Avicel PH-200 microcrystalline cellulose NF, Ph. Place an order online, track your orders, download SDS and TDS, and see your quotes, all in one secure place. It works as a moisture sponge and permits the controlled growth of spheroids. In many applications, one METHOCEL product can perform the job of two, three or even more ingredients saving money and time. if interested in purchasing or obtaining a sample for assessment, you should contact Dupont themselves directly. Product Name: Microcrystalline Cellulose E460 1.2. No. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. POLYOX resins are nonionic polyethylene oxide solubility polymers. xv}O2' H~KEe9>G/,:9\i AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. stream Pharmacel 112 is a directly compressible microcrystalline cellulose grade with a low moisture content (LOD Max. The data shown below apply only to Avicel PH 101. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. Millipore. Alubra is also less susceptible to over-blending contributing to more flexible process conditions and reduced waste due to over blended batch failures. Examination of urine, blood and faecal levels of vitamin B 1 during microcrystalline cellulose ingestion showed no difference from control periods (Anonymous, 1966). It is insoluble in water, dilute acids, common organic solvents and oils, partially soluble with . /Contents 4 0 R Molecular weight: Not Applicable 1.5. stream MATERIAL SAFETY DATA SHEET Version: 1.0 1. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. To overcome the pitfalls of known overlays, we tested suspensions of microcrystalline cellulose Avicel RC/CLtrade mark as overlay media in the plaque and plaque-inhibition assay of influenza viruses. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Avicel RC-591 offers ideal thixotropic bahavior for stabilizing suspensions while Avicel CL-611 is a stabilizer for reconstitutable or dry suspension formulations. <> Eur., JP Product Specifications: Chemical and Physical: Loss on drying 2.0 - 5.0 %* Bulk density 0.29 - 0.36 g/cc Identification A, B Passes Degree of polymerization NMT 350 units pH 5.5 - 7.0* Conductivity NMT 75 S/cm Comprecel MCC (Microcrystalline Cellulose) is a pharmaceutical excipient derived from nature's most abundant and renewable raw material-wood pulp. FMC Corporation. CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. MATERIAL SAFETY DATA SHEET Avicel PC 611 Microcrystalline Cellulose Page 1 of 8 MSDS Ref. Avicel Microcrystalline cellulose is a type of cellulose, a naturally-occurring, large molecular weight polysaccharide found in woody plants. Alginates from IFF are an excellent choice for consistent performance in a variety of applications. Origin(s): Plant/Botanical. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Truly distinctive drug delivery solutions. Thus, Avicel contributes no or very few calories to the food system. There may be more fiber in your food than you realized. GENERIC EU MSDS - NO COUNTRY SPECIFIC DATA - NO OEL DATA 1. The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. pH 6.0 to 8.0 . Microcrystalline Cellulose, Colloidal Silicon Dioxide: 50: 0.20 - 0.30: Best in class binder. (&E. gac74 [#B6`Wnw7 The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Earth Supplied Products LLC. msdsinfo@fmc.com (Email - General Information) FMC Europe NV Avenue Mounier 83 1200 Brussels, Belgium 353 21 435 4133 (General Information - Cork, Avicel PH-101. endobj The MCC can be synthesized by different processes such as reactive extrusion, enzyme mediated, steam explosion, and acid hydrolysis. /Group << /S /Transparency /CS /DeviceRGB /I false /K false >> <> Chemical Formula: (C6H10O5)n 1.4. Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. Fiber supplements can lessen the absorption of some . Safety Data Sheet (SDS) Viewer. 86dXeaAjHe%d*`&>>&_p}=X|_% fTtC aB s!YaxHWtGr"GQ 5S"fMS+_;x@@5 zjrK=;OA:il)b> e ei'wm~oh!=Z@Y:J0#8On`T./iC}^o%7KS"$ rf*Z;JTL-uOHH%%Z,029J_ ( endstream endobj 526 0 obj 465 endobj 527 0 obj << /Filter /FlateDecode /Length 526 0 R >> stream MATERIAL SAFETY DATA SHEET Avicel PH Microcrystalline Cellulose MSDS Ref. Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. It is generally regarded as a relatively nontoxic and non-irritant material that is safe for human and animal consumption. Combines good flow and high compactibility. Synergies to simplify formulation challenges and reduce operational costs. Micro Crystalline Cellulose. No. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . EMCOCEL XLM 90. Learn about FMC's industry leading goal of net-zero emissions by 2035. Microcrystalline cellulose -The oldest polymer finds new industrial uses,. CAS #: 9004-34-6 1.6. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. MATERIAL SAFETY DATA SHEET. 4. It is . Innovation is at the heart of IFFs purpose of applying science and creativity to create a better world. Avicel Microcrystalline Cellulose Physical Properties. vdZ@Rgl{eU+7N!3!|hUmW)~}U*7k i@j)q["MEydtP"ftFu]t }JN~A"8lz7#}J.i@ qaj/QU<5OrVMfl{pL? endobj EMCOCEL 90 M. 130. : 160182 Date Approved: 05/25/2010 Revision No. Carrageenan is a naturally occurring family of hydrophilic polysaccharides extracted from several closely related species of red seaweeds. stream AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. The cellulose molecule is formed through repeated condensation of cellobiose units. } !1AQa"q2#BR$3br Generally, these can be classified into two broad groups: Standard grades, and Co-processed grades. The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. The 'Substance identity' section is calculated from substance identification information from all ECHA databases. Avicel co-processed products are high functionality excipients offering improved powder flow, granule properties, tablet compression, and mouth feel. 4 0 obj . Have an order or account question, find answers in our Online Support articles. 0.25 - 0.37. Microcrystalline Cellulose / Avicel PH-102. 10.1 Future Forecast of the Global Microcrystalline Cellulose Market from 2023-2028 Segment by Region 10.2 Global Microcrystalline Cellulose Production and Growth Rate Forecast by Type (2023-2028 . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. endobj Battista, O. Request media, explore upcoming events and read our latest updates. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. The aqueous solution to barrier membrane coating. Microcrystalline Cellulose / Avicel PH-102. P}MFbN#[>r(y However, if handling bulk powders, observance of appropriate safeguards is recommended. (Microcrystalline Cellulose Market Pr. Material Safety Data Sheet or SDS for Cellulose microcrystalline 102331 from Merck for download or viewing in the browser. Microcrystalline cellulose (MCC) is one of the most important tableting excipients thanks to its outstanding dry binding properties, enabling the manufacture of tablets by direct compression (DC). Well-recognized product that can do it all. w !1AQaq"2B #3Rbr "R}~Q:~pgg'"l/O:OV~ @zo7g;)K;=d'}z8}7w7?Iuw?w~ikK^^'d4k;g_u_LOC6($uiz["Dw#j{ogw~0B"ty'{DqXmImPiww#({LDo^/w;?EW>;b$l/fmQ-1GG/jls}>N\UbZWi,`:O?e;hD8}uC?L{yiD>_2?0 :f =eU}|r=r?P5){{o:tzY- F kNdOaM;p0Nmm7A!Va/eWzgT5vw Ur?0J. PDF (2.77 mb) 2021 FMC Sustainability Report. The United States Food and Drug Administration considers microcrystalline cellulose a safe material for all animal species. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Eur., JPE . BIOACCUMULATIVE POTENTIAL Formulators select it when they need to enhance a formulations robustness especially when less compactable diluents and binders are used. 2 0 obj No. . It is a white, free-flowing powder. By producing Avicel . LOT #: Available upon request. Currently, it is marketed both directly and indirectly (through distributors) depending on the country in question. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Avicel Microcrystalline cellulose was discovered in 1955 by a team at FMC Corporation, led by the legendary Canadian-born chemist, Orlando Aloysius Battista, which he initially named mechanically disintegrated D.P cellulose. << Report Category. Note that Avicel Microcrystalline cellulose is available in different particle sizes and moisture grades that have different properties and applications. Accumulation of overhead settled dust may form explosive concentrations in air when disturbed and dispersed. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Product Name: Microcrystalline Cellulose 1.2. Remove Chemically, it is an inert substance, is not degraded during digestion and has no appreciable absorption. : 9004-34-6 Date Approved: 01/31/2008 . This unique functionality can be used in a diversity of applications such as controlled release dosage forms, enteric coatings, microencapsulation and stabilization in solutions and suspensions. X]s ;/4'OslUK:|QY`IL|w @ I!*2T~IN?*}y2*49]yOQ*VG%Gu,;&9zE{q==xvrv}rd(yG*qN6E0K$IBWhe "l%I-*j|-)@ EtG[TQd%8,.fg4QqH'-dV ?3Z#GK# dGnF7x*3yY\VUwPhmyYT@f67Zcsmdi!%94K@:L# vJeU-kzRT-(YX/fKC Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. The chemical structure of cellulose is shown below: In the biosynthesis of cellulose, two molecules of -D-glucose molecules combine via a condensation reaction (elimination of one molecule of water) to form the so-called cellobiose unit. MATERIAL SAFETY DATA SHEET Avicel RC/CL Microcrystalline Cellulose and Sodium Carboxymethylcellulose MSDS Ref. Doses up to 30 g per day appear to be . LATTICE Microcrystalline Cellulose has many important uses within the food, pharma, specialty applications and industrial such . microcrystalline cellulose and carboxymethylcellulose sodium NF, Ph. SUBSTANCE IDENTIFICATION 1.1. The formed cellulose molecules pack themselves closely to each other, stabilised through hydrogen bonds, creating crystalline regions interspersed with amorphous regions. Microcrystalline cellulose (C6H10O5)n is refined wood pulp. To help, weve put together a simple guide for selecting Avicel Microcrystalline cellulose grades, with simple explanations of some of the most common grades, plus recommendations that will serve the majority of buyers. AFFINISOL hydroxypropyl methylcellulose (HPMC) is a water-soluble cellulosic polymer that can help optimize solubility enhancement of poorly soluble drugs by maintaining stable solid dispersions and inhibiting API crystallization. Superior Performance: Provides excellent water uptake and rapid swelling . CAS 9004-34-6. PharmaCentral 2021 . Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. : 160182. 3 0 obj The typical mean particle size is 20200 m. Alginates also function as actives in some anti-reflux products. GRINDSTED Xanthan Gum is a naturally fermented product of carbohydrates and is applied in various liquid, semi-solid and solid pharmaceutical dosage forms. Are you sure you want to delete your template? /MediaBox [0 0 612 792] Van Veen, G.K. Bolhuis, Y.S. 1.3. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. }o]X4]. SUBSTANCE IDENTIFICATION 1.1. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. 4 0 obj : CL-611NF Date Approved: 01/13/2010. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. : 5. ( Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. gwf;J(e0o|1p{R~P^);ao!%{0KD7. However, consumption of large quantities of the material may have a laxative effect. Learn about FMC's differentiated biologically-based crop solutions. ]2}Sb2Wdn-;^}n(/;r\'l3--l~ kuI?H>$7;!l|g|i4&dtb/O3!C!#\qpg+>Q0OM Avicel Microcrystalline Cellulose: Chemical Identifiers. Product and Company Identification . Pharmacel 112 can be used in a wide range of oral solid dosage (OSD) forms as binder, compressing agent . These grades have particle sizes ranging from <30 to approximately 200. All Rights Reserved. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose . Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. Wu, K. Zuurman, H.W. Synonyms: Cellulose, Cellulose powder, Cotton linters. 1 0 obj Upon ingestion, microcrystalline cellulose is not absorbed into the blood stream and therefore has little toxicological potential. %PDF-1.4 CAS #: 9004-34-6 . SCMm_>x^O9l (n. ChemicalBook. If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 April 21st, 2019 - Material Safety Data Sheet Ethyl Alcohol 70 ACC 91791 Section 1 Chemical Product and Company Identification Ethanol has been shown to produce fetotoxicity in the embry o or fetus of laboratory animals Prenatal Chemical waste generators must determine stream Product and Company Identification Product Name Microcrystalline Cellulose CAS Number 9004-34-6 Parchem - fine & specialty chemicals 415 Huguenot Street New Rochelle, NY 10801 (914) 654-6800 (914) 654-6899 parchem.com info@parchem.com EMERGENCY RESPONSE NUMBER From anti-reflux to biomedical implants, alginates are uniquely suited for a wide range of applications. They are high molecular weight, highly sulfated, linear molecules with a galactose backbone. Validity Area. Page 1 of 8. Cellulose microcrystalline. }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. cas:9000-11-7 msds Carboxymethyl cellulose. on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. They are differentiated from each other by the amount of 3,6-anhydrogalactose as well as the number and position of ester sulfate groups present. Some substance identifiers may have been claimed confidential, or may . F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. 1 0 obj This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. It is hygroscopic and insoluble in water. This paper is based on a study of the interactions that take place during the process of hydrogel formation, break down, and recovery. Date Approved: 05/25/2010. lH5JWy}DgKRR"Fs Ac-Di-Sol Croscarmellose Sodium is one of our flagship offerings for pharmaceutical manufacturers. The most. Fmc Corporation: Ultra-fine microcrystalline cellulose compositions and process . METHOCEL cellulose ethers are water-soluble polymers derived from cellulose. Biologicals by FMC. Microcrystalline cellulose 9004-34-6 232-674-9 Not Listed * Magnesium stearate 557-04- 209-150-3 Not Listed * . It is, however, a good source of fibre. Document(s): certificate data msds. FMC Corporation: Co-processed microcrystalline cellulose and sugar alcohol as an excipient for tablet formulations DE102009022738A1 (de) * 2009-05-26: 2010-12-09: J. Rettenmaier & Shne Gmbh + Co. Kg . However, it yields non-digestible fibre. Hi, let us know if you have any questions as you visit our website. Apply today! In the late 1960s, Avicel Microcrystalline cellulose was registered in the supplement to the National Formulary as a pharmaceutical excipient. Meet our leadership team. Solid dispersions are one of the key technologies for formulating oral solid dosage forms containing APIs with bioavailability challenges. /Type/Page >> It . Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Molecular Weight null. CAS No. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. MSDS Ref. IFF has decades of experience controlling these naturally derived materials, which means you can count on consistent performance, every time. Microcrystalline cellulose has excellent compressibility properties and is widely used in solid forms such as tablets that are hard, but can dissolve quickly, and this has increased its demand in . Avicel Microcrystalline cellulose also serves as a moisture adsorbent and as a general-purpose formulation improver. Avicel Microcrystalline Cellulose: A Guide to Grades and Uses, Working Hours (Mon to Friday): 08:30 - 17:30, legendary Canadian-born chemist, Orlando Aloysius Battista, United States Pharmacopoeia and National Formulary, United States Food and Drug Administration, Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g), https://doi.org/10.1016/0378-5173(95)04231-8, https://doi.org/10.1016/j.ejpb.2004.05.009, https://doi.org/10.1002/9783527682935.ch04, Pharmaceutical Acronyms and Abbreviations, Glossary of Terms Used in the Pharmaceutical Industry, Standard Terms & Conditions Of Sale Of Goods And Services, 4-O-[(1S)-hexopyranosyl]-D-glycero-hexopyranose. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). Patel, F. Podczeck, Investigation of the effect of type and source of Microcrystalline Cellulose on capsule filling, International Journal of Pharmaceutics, 128 (1996) 123-127.

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